ATM mediated-p53 signaling pathway forms a novel axis for senescence control.

Su Young Hwang, Myeong Uk Kuk, Jae Won Kim, Yun Haeng Lee, Young-Sam Lee, Hyon E Choy, Sang Chul Park, Joon Tae Park

Mitochondrion 2020 Nov

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Previously, we uncovered a novel mechanism in which senescence is controlled by mitochondrial functional recovery upon Ataxia-telangiectasia mutated (ATM) inhibition. However, it remains elusive how ATM controls signaling pathways to achieve restorative effect. In this study, we performed microarray and found that p53 pathway was differentially expressed upon ATM inhibition. We found that ATM inhibition yields senescence amelioration through p53-dependent manner. The restorative effect was also afforded by direct p53 inhibition. Furthermore, mitochondrial metabolic reprogramming via p53 inhibition was a prerequisite for senescence amelioration. Taken together, our data indicated that p53 pathway functions as potential target for ATM-mediated senescence amelioration. Copyright © 2020 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Citation

Su Young Hwang, Myeong Uk Kuk, Jae Won Kim, Yun Haeng Lee, Young-Sam Lee, Hyon E Choy, Sang Chul Park, Joon Tae Park. ATM mediated-p53 signaling pathway forms a novel axis for senescence control. Mitochondrion. 2020 Nov;55:54-63