A case of dasatinib-induced focal segmental glomerulosclerosis in a patient with Philadelphia chromosome positive chronic myeloid leukemia.

Ezgi Ersoy Yesil, Dede Sit, Hasan Kayabasi, Fatima Zerenler Gursoy, Mustafa Behcet Demirbas, Sibel Ocak Serin

Nephrologie & therapeutique 2021 Feb

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Focal segmental glomerulosclerosis is a common glomerular histological lesion, which is usually characterised by non-nephrotic range proteinuria or nephrotic syndrome. It may be idiopathic or occurs secondarily to drugs, diabetes, obesity or HIV nephropathy and other infections. Dasatinib, a tyrosine kinase inhibitor that has been used for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia, has a few renal adverse effects. Exceptional cases with non-nephrotic range proteinuria have been reported in relation with dasatinib. In this case, we report a patient with symptoms of nephrotic syndrome and nephrotic range proteinuria, who was diagnosed as focal segmental glomerulosclerosis by kidney biopsy after treated with dasatinib. Copyright © 2020 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.

Citation

Ezgi Ersoy Yesil, Dede Sit, Hasan Kayabasi, Fatima Zerenler Gursoy, Mustafa Behcet Demirbas, Sibel Ocak Serin. A case of dasatinib-induced focal segmental glomerulosclerosis in a patient with Philadelphia chromosome positive chronic myeloid leukemia. Nephrologie & therapeutique. 2021 Feb;17(1):53-56