Effectively reducing antibiotic contamination and resistance in fishery by efficient gastrointestine-blood delivering dietary millispheres.

The overuse of antibiotics during the medication treatment is inevitable in the extensively-applied intensive and semi-intensive aquaculture mode; the accompanied antibiotic contamination and antimicrobial resistance pose threats to the ecosystems and cause great loss to the aquaculture industry. To solve the problem, this work introduced the antibiotic-laden dietary millispheres (DMSs) with internal porous structure for the high availability, attractiveness and digestibility to fish. Two types of antibiotics with distinct solubilities - tetracycline chloride (TCH) and sulfadiazine (SDZ) were made into the DMSs, individually, which were then directly adopted in the feeding of fish. Carassius auratus was chosen as the target fish in this work. The mesocosm study demonstrate that, compared with the regular way of oral administration (feeding the mixture of antibiotics and commercial feed pellets), the DMSs could use much less (i.e. one order of magnitude lower) antibiotic dose to reach the equivalent antibiotic concentration in gastrointestine and blood. As a robust alternative, either TCH- or SDZ-laden DMSs achieved efficient drug delivery in vivo, which importantly facilitated the source reduction of antibiotics, the alleviation of antibiotic contamination in fishery and the control of antibiotic resistance especially in sediments. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Ming Zhang, Zhongxia Cai, Guofu Zhang, Yin Zhang, Nana Xue, Daoyong Zhang, Xiangliang Pan. Effectively reducing antibiotic contamination and resistance in fishery by efficient gastrointestine-blood delivering dietary millispheres. Journal of hazardous materials. 2021 May 05;409:125012

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PMID: 33440322

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