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Targeting WASF3 Signaling in Metastatic Cancer.
Reid Loveless, Yong Teng
International journal of molecular sciences 2021 Jan 15
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Increasing evidence indicates that cancer metastasis is regulated by specific genetic pathways independent of those controlling tumorigenesis and cancer growth. WASF3, a Wiskott-Aldrich syndrome protein family member, appears to play a major role not only in the regulation of actin cytoskeleton dynamics but also in cancer cell invasion/metastasis. Recent studies have highlighted that WASF3 is a master regulator and acts as a pivotal scaffolding protein, bringing the various components of metastatic signaling complexes together both spatially and temporally. Herein, targeting WASF3 at the levels of transcription, protein stability, and phosphorylation holds great promise for metastasis suppression, regardless of the diverse genetic backgrounds associated with tumor development. This review focuses on the critical and distinct contributions of WASF3 in the regulation of signal pathways promoting cancer cell invasion and metastasis.
Citation
Reid Loveless, Yong Teng.
Targeting WASF3 Signaling in Metastatic Cancer.
International journal of molecular sciences.
2021 Jan 15;22(2)
Mesh Tags
ATPases Associated with Diverse Cellular Activities
Animals
Cell Movement
Gene Expression Regulation, Neoplastic
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Janus Kinase 2
Membrane Proteins
Mice
MicroRNAs
Mitochondrial Proteins
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms
Phosphatidylinositol 3-Kinases
Phosphorylation
STAT3 Transcription Factor
Signal Transduction
Wiskott-Aldrich Syndrome Protein Family
Substances
ATAD3A protein, human
HIF1A protein, human
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Hypoxia-Inducible Factor 1, alpha Subunit
Membrane Proteins
MicroRNAs
Mitochondrial Proteins
STAT3 Transcription Factor
STAT3 protein, human
WASF3 protein, human
Wasf3 protein, mouse
Wiskott-Aldrich Syndrome Protein Family
JAK2 protein, human
Janus Kinase 2
ATPases Associated with Diverse Cellular Activities
molecular chaperone GRP78
PMID: 33467681
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