Correlation Engine 2.0
Clear Search sequence regions


  • heart failure (1)
  • humans (1)
  • lamin (2)
  • LMNA (1)
  • patients (2)
  • progeria (4)
  • teens (1)
  • Sizes of these terms reflect their relevance to your search.

    The ultra-rare, pediatric premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS) is caused by mutation of LMNA, encoding the nuclear architectural protein lamin A. Patients develop atherosclerosis and typically die of heart failure in their teens. FDA-approved Zokinvy prevents farnesylation of lamin A, reduces vascular stiffness, and extends survival in HGPS patients. To view this Bench to Bedside, open or download the PDF. Copyright © 2020. Published by Elsevier Inc.

    Citation

    Tom Misteli. Farnesyltransferase inhibition in HGPS. Cell. 2021 Jan 21;184(2):293

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 33482093

    View Full Text