MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast.

Tiffany G Sheu, Kelly K Hunt, Lavinia P Middleton

The breast journal 2021 Mar

filter terms:

Postradiation cutaneous angiosarcoma of the breast is a rare, delayed complication of adjuvant radiation treatment for breast carcinoma and is associated with a worse prognosis than the original primary cancer. Recent studies have characterized the diagnostic utility of MYC and NOTCH1 receptor expression as markers for secondary radiation-associated angiosarcomas. Herein, we report an exophytic secondary breast angiosarcoma with MYC and NOTCH1 immunoreactivity. This case illustrates the utility of these markers for the identification of radiation-associated angiosarcoma with MYC and NOTCH1 expression, potential for targeted therapy and need to identify patients for further studies of the clinicopathologic and prognostic significance. © 2021 Wiley Periodicals LLC.

Citation

Tiffany G Sheu, Kelly K Hunt, Lavinia P Middleton. MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast. The breast journal. 2021 Mar;27(3):264-267