Successful treatment with ponatinib in combination with hyper-CVAD for chronic myeloid leukemia in the lymphoid blastic phase].

Seiji Kakiuchi, Junpei Rikitake, Hiroki Kitazawa, Isamu Harima, Riku Nakajima, Hiroaki Akiyama, Hiroyuki Matsuba, Shiho Nagata, Ikumi Takagi, Nobuko Iwata

[Rinsho ketsueki] The Japanese journal of clinical hematology 2021

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The prognosis of chronic myeloid leukemia (CML) has improved dramatically with the introduction of tyrosine kinase inhibitors. Although the use of second-generation tyrosine kinase inhibitors is now available for initial cases, a small number of patients with CML unfortunately still experience progression to the accelerated or blastic phase of the disease. We recently managed a patient with chronic-phase CML, who developed a T315 mutation early in the course of treatment with dasatinib and progressed to the lymphoid blastic phase. The patient responded quickly to ponatinib therapy in combination with hyper CVAD, leading to cord blood transplantation. We report here the first case of a patient with CML in the lymphoid blastic phase treated with ponatinib in combination with hyper CVAD, which was tolerable despite adverse events such as infection, bilirubin elevation, and hypertension, and who was able to proceed to transplantation after achieving a complete molecular response.

Citation

Seiji Kakiuchi, Junpei Rikitake, Hiroki Kitazawa, Isamu Harima, Riku Nakajima, Hiroaki Akiyama, Hiroyuki Matsuba, Shiho Nagata, Ikumi Takagi, Nobuko Iwata. Successful treatment with ponatinib in combination with hyper-CVAD for chronic myeloid leukemia in the lymphoid blastic phase]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2021;62(1):47-50