Ning Wang, Weining Zhang, Yujie Chen, Ya Cao, Zhifang Hu, Fengliang Jiang
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2021 MarChronic inflammatory damage of intestinal mucosa is an important characteristic of inflammatory bowel disease (IBD). Studies have shown that the interleukin 23 (IL-23)/IL-17 axis is involved in intestinal mucosal inflammatory injury and plays a crucial role in the development and prognosis of IBD. IL-23 is one of the upstream molecules of IL-17, which can promote Th17 cell activation, proliferation and the secretion of inflammatory cytokines. Moreover, IL-23 is involved in the inflammatory response process of various immune cells such as neutrophils, macrophages, regulatory T cells (Tregs), the group 3 innate lymphocytes (ILC3) during IBD. Previous studies demonstrated that IL-23 and IL-17 increased in IBD, which lead to an imbalance between Tregs and auto-reactive T cells to exacerbate the inflammatory pathological damage of the intestinal mucosa. Notably, although IL-23/IL-17 is potential therapeutic target for inflammation-related diseases and anti-IL-23 strategies has proven to be effective in treating IBD, the strategy of blocking IL-17 to treat IBD has failed. Therefore, a deep understanding of the relationship between IL-17/IL-23 axis and IBD is necessary for the study of IBD treatment.
Ning Wang, Weining Zhang, Yujie Chen, Ya Cao, Zhifang Hu, Fengliang Jiang. Progress on relationship between IL-23/IL-17 axis and inflammatory bowel disease]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2021 Mar;37(3):271-277
PMID: 33766235
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