Immunomodulatory and protective effects of interleukin-4 on the neuropathological alterations induced by a potassium channel blocker.

Nesrine Ahras-Sifi, Fatima Laraba-Djebari

Journal of neuroimmunology 2021 Jun 15

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The pathophysiology of neurological diseases related to potassium-channel dysfunction such as epilepsy is increasingly linked to immune system modulation. However, there are limited reports of which interleukin-4 (IL-4) can act on the neuroinflammatory response after seizure. Hence, we evaluated the effect of IL-4 in murine model of neuroexcitotoxcity using kaliotoxin (KTx), a potassium-channel blocker. Results showed that IL-4 treatment can significantly reduce the neuronal death induced by KTx. Probably by decreasing mitochondria swelling, reversing oxidative damage and enhancing Bcl-2 expression. Furthermore, IL-4 treatment significantly reduced TNF-α expression and enhanced GFAP and IL-10 expressions in the brain. IL-4 can be neuroprotective in epileptogenesis. Copyright © 2021. Published by Elsevier B.V.

Citation

Nesrine Ahras-Sifi, Fatima Laraba-Djebari. Immunomodulatory and protective effects of interleukin-4 on the neuropathological alterations induced by a potassium channel blocker. Journal of neuroimmunology. 2021 Jun 15;355:577549