Ethereal Extract of Pepper: Preventing Atherosclerosis and Left Ventricle Remodeling in LDL Receptor Knockout Mice.

Cardiovascular diseases are the leading cause of mortality and morbidity worldwide. In this study we compared the effects of oral treatment with red pepper ethereal extracts or simvastatin on dyslipidemia, left ventricle remodeling, and atherosclerotic lesions of low-density lipoprotein (LDL) receptor knockout mice (LDLr-/-) fed a hyperlipidic diet. Forty 3-month-old male mice were distributed into four groups: control (C; animals fed a standard diet), HL (ani-mals fed a hyperlipidic diet), and HL+P or HL+S (animals fed a hyperlipidic diet plus red pepper ethereal extracts or simvastatin, respectively). After 60 days, treatment with both red pepper ethereal extracts and simvastatin prevented dyslipidemia, atherosclerotic lesion progression, and left ventricle hypertrophy. Our results suggest a cardioprotective effect of red pepper ethereal extracts in LDLr-/- mice, which is comparable to the well-known effects of simvastatin. Copyright © 2021 by The Korean Society of Food Science and Nutrition. All rights Reserved.

Citation

Leandro Dos Santos, Letícia de Oliveira Maciel, Erika Kristina Incerpi Gracia, Evelise Aline Soares, Danielle Aparecida Quintino Silva Sarto, Valério Garrone Barauna, Heder Frank Gianotto Estrela, Carollayne Mendonça Rocha, Maria das Graças de Souza Carvalho, Brígida Monteiro Vilas Boas, José Antônio Dias Garcia. Ethereal Extract of Pepper: Preventing Atherosclerosis and Left Ventricle Remodeling in LDL Receptor Knockout Mice. Preventive nutrition and food science. 2021 Mar 31;26(1):51-57

PMID: 33859959

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