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Brugada syndrome (BS) is a hereditary cardiac disease leading to sudden cardiac death. It does not display any structural cardiac abnormalities. It was first described in 1992, as the syndrome of 'right bundle branch block, persistent ST segment elevation, and sudden death.' Brugada phenocopy (BP) is a relatively new term used to describe electrocardiogram (ECG) patterns that resemble BS but are due to other reversible causes such as electrolyte abnormalities, fever, cocaine or alcohol intoxication, and side effect of certain medications such as sodium channel blockers, beta blockers, antidepressants, alpha adrenergic blockers, etc. Earlier studies have shown that patients taking sodium channel blocking antiepileptic drugs (AEDs) especially phenytoin can have Brugada type 1 like ECG pattern. Previously, type 2 ECG pattern secondary to supra-therapeutic phenytoin level has not been described. We describe a case with type 2 Brugada ECG pattern due to supra-therapeutic phenytoin level; the ECG pattern completely resolved following lowering the phenytoin to a therapeutic level. These patients need special considerations in ED management, disposition, and follow-up. Copyright © 2021, Iftikhar et al.


Haris Iftikhar, Khalid Bashir. Type 2 Brugada Electrocardiogram Pattern Due to Supra-Therapeutic Phenytoin Level. Cureus. 2021 Apr 09;13(4):e14381

PMID: 33976997

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