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The DNA repair proteins FAN1 and MLH1 have opposing effects on triplet repeat expansions. New studies by Goold et al. (2021) and Porro et al. (2021) pinpoint interactions between FAN1 and MLH1 that cross-regulate each other's activities. Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.


Robert S Lahue. SPYing on triplet repeat expansions: Insights into FAN1-MLH1 interaction and regulation. Cell reports. 2021 Sep 14;36(11):109736

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PMID: 34525375

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