Role of Interleukin-17 in Acute Pancreatitis.

Guanqun Li, Hongze Chen, Liwei Liu, Peng Xiao, Yu Xie, Xinglong Geng, Tao Zhang, Yang Zhang, Tianqi Lu, Hongtao Tan, Le Li, Bei Sun

Frontiers in immunology 2021

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Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by systemic manifestations that are generally associated with a poor prognosis. Many cytokines contribute to pancreatic tissue damage and cause systemic injury. Interleukin-17 (IL-17) is a cytokine that may play a vital role in AP. Specifically, IL-17 has important effects on the immune response and causes interactions between different inflammatory mediators in the AP-related microenvironment. In this literature review, we will discuss the existing academic understanding of IL-17 and the impacts of IL-17 in different cells (especially in acinar cells and immune system cells) in AP pathogenesis. The clinical significance and potential mechanisms of IL-17 on AP deterioration are emphasized. The evidence suggests that inhibiting the IL-17 cytokine family could alleviate the pathogenic process of AP, and we highlight therapeutic strategies that directly or indirectly target IL-17 cytokines in acute pancreatitis. Copyright © 2021 Li, Chen, Liu, Xiao, Xie, Geng, Zhang, Zhang, Lu, Tan, Li and Sun.

Citation

Guanqun Li, Hongze Chen, Liwei Liu, Peng Xiao, Yu Xie, Xinglong Geng, Tao Zhang, Yang Zhang, Tianqi Lu, Hongtao Tan, Le Li, Bei Sun. Role of Interleukin-17 in Acute Pancreatitis. Frontiers in immunology. 2021;12:674803