A quinoline derived D-A-D type fluorescent probe for sensing tetrameric transthyretin.

Fantao Sun, Jinsheng Liu, Yanan Huang, Xinyin Zhu, Yu Liu, Lei Zhang, Jinwu Yan

Bioorganic & medicinal chemistry letters 2021 Nov 15

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Nowadays, with an upward trend in the prevalence of intracerebral amyloidosis, it is of great significance to use fluorescent probes for early diagnosis in vitro. In this study, a quinoline-derived D-A-D type chemosensor was rationally designed and synthesized as a probe for the sensitive detection of tetrameric transthyretin (WT-TTR). Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Fantao Sun, Jinsheng Liu, Yanan Huang, Xinyin Zhu, Yu Liu, Lei Zhang, Jinwu Yan. A quinoline derived D-A-D type fluorescent probe for sensing tetrameric transthyretin. Bioorganic & medicinal chemistry letters. 2021 Nov 15;52:128408