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    The slick-hair phenotype in cattle is due to one of a series of mutations in the prolactin receptor (PRLR) that cause truncation of the C-terminal region of the protein involved in JAK2/STAT5 activation during prolactin signaling. Here we evaluated whether the inheritance of the SLICK1 allele, the first slick mutation discovered, is inherited in a fashion consistent with Hardy-Weinberg equilibrium. It was hypothesized that any deleterious effect of inheriting the allele on embryonic or fetal function would result in reduced frequency of the allele in offspring. A total of 525 Holstein and Senepol cattle produced from matings involving one or both parents with the SLICK1 allele were genotyped. The observed frequency of the SLICK1 allele (0.247) was not significantly different than the expected frequency of 0.269. These results support the idea that inheritance of the SLICK1 allele does not act in the embryo or fetus to modify its competence to complete development to term. © 2021 Stichting International Foundation for Animal Genetics.


    F Sosa, A T Carmickle, E Jiménez-Cabán, M S Ortega, S Dikmen, V Negrón-Pérez, E A Jannaman, A Baktula, G Rincon, C C Larson, M Pagán-Morales, A C Denicol, T S Sonstegard, P J Hansen. Inheritance of the SLICK1 allele of PRLR in cattle. Animal genetics. 2021 Dec;52(6):887-890

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    PMID: 34642995

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