SULT1A1 and SULT1A2 Associated Extensive Prolapse-Type Inflammatory Polyposis in Crohn's Colitis.

Ting Zhou, Kalyani Patel, R Alan Harris, Victor Seghers, Seema M Walsh, Ruben Rodriguez, Richard Kellermayer, Hao Wu

Annals of clinical and laboratory science 2021 Nov

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Mucosal prolapse syndrome most commonly involves the rectum and presents as solitary rectal ulcer syndrome and proctitis cystica profunda. Symptoms and endoscopic appearances are nonspecific. Histologically, mucosal prolapse is characterized by fibromuscular obliteration of the lamina propria, and displacement of crypts into submucosa and muscularis mucosae. Mucosal prolapse presenting as polyposis is rare and has only been reported involving the rectosigmoid colon. In this report, we describe a case of mucosal prolapse syndrome presenting as diffuse polyposis and colitis cystica profunda involving the hepatic, splenic flexures and descending colon in a teenage boy suffering from refractory fibrostenosing Crohn's disease. This patient was found to have possibly deleterious homozygous single nucleotide polymorphisms in both SULT1A1 and SULT1A2 genes within a unique polygenic variation of altered cell adhesion. © 2021 by the Association of Clinical Scientists, Inc.

Citation

Ting Zhou, Kalyani Patel, R Alan Harris, Victor Seghers, Seema M Walsh, Ruben Rodriguez, Richard Kellermayer, Hao Wu. SULT1A1 and SULT1A2 Associated Extensive Prolapse-Type Inflammatory Polyposis in Crohn's Colitis. Annals of clinical and laboratory science. 2021 Nov;51(6):868-874