Eric D Deihl, Luke T Jesikiewicz, Logan J Newman, Peng Liu, Kay M Brummond
Organic letters 2022 Feb 04Thapsigargin (Tg) is a potent SERCA pump inhibitor with the potential to treat cancer and COVID-19. We have extended the scope of the asymmetric allenic Pauson-Khand reaction to furan-tethered allene-ynes, a stereoconvergent transformation affording the 5,7,5-ring system of Tg in good yields and high enantioselectivity. Computational studies of the oxidative cyclization step show that the furan and chloroacetate groups contribute to this high selectivity.
Eric D Deihl, Luke T Jesikiewicz, Logan J Newman, Peng Liu, Kay M Brummond. Rh(I)-Catalyzed Allenic Pauson-Khand Reaction to Access the Thapsigargin Core: Influence of Furan and Allenyl Chloroacetate Groups on Enantioselectivity. Organic letters. 2022 Feb 04;24(4):995-999
PMID: 35081313
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