Uric Acid and Oxidative Stress-Relationship with Cardiovascular, Metabolic, and Renal Impairment.

Mihai-Emil Gherghina, Ileana Peride, Mirela Tiglis, Tiberiu Paul Neagu, Andrei Niculae, Ionel Alexandru Checherita

International journal of molecular sciences 2022 Mar 16

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The connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging studies allege a new hypothesis concerning UA and renal impairment involving a pro-inflammatory status, endothelial dysfunction, and excessive activation of renin-angiotensin-aldosterone system (RAAS). Additionally, hyperuricemia associated with oxidative stress is incriminated in DNA damage, oxidations, inflammatory cytokine production, and even cell apoptosis. There is also increasing evidence regarding the association of hyperuricemia with chronic kidney disease (CKD), cardiovascular disease, and metabolic syndrome or diabetes mellitus. Important aspects need to be clarified regarding hyperuricemia predisposition to oxidative stress and its effects in order to initiate the proper treatment to determine the optimal maintenance of UA level, improving patients' long-term prognosis and their quality of life.

Citation

Mihai-Emil Gherghina, Ileana Peride, Mirela Tiglis, Tiberiu Paul Neagu, Andrei Niculae, Ionel Alexandru Checherita. Uric Acid and Oxidative Stress-Relationship with Cardiovascular, Metabolic, and Renal Impairment. International journal of molecular sciences. 2022 Mar 16;23(6)