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QuickView for renal impairment (phenotype)


Genetic Markers

Most Correlated Genes

Most Correlated SNPs

  1. CD46
  2. CFH
  3. EGR1
  4. C3
  5. VPS33B
  1. No SNPs found
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Pathway Enrichment

Most Correlated Biogroups

  1. immune response
  2. REACTOME_IMMUNE_SYSTEM
  3. response to stress
  4. regulation of immune response
  5. vesicle
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Curated Studies

Most Correlated Studies

  1. Whole blood expression profiles of uremic patients
  2. Kidneys from renal ablation CKD mouse model treated with aliskiren and losartan.
  3. CD4+ T cells from an atypical hemolytic uremic syndrome (aHUS) patient carrying mutant CD46
  4. OMIM - Anemia
  5. Kidney from patients with normal and dysfunctional renal allografts
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Literature

Most Relevant Literature

  1. Effect of severe renal impairment on pharmacokinetics, safety, and tolerability of lemborexant.
  2. Effect of Severe Renal Impairment on the Safety, Tolerability, and Pharmacokinetics of AMG 986.
  3. Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.
  4. Pharmacokinetics of bempedoic acid in patients with renal impairment.
  5. Hyperuricemia and Impaired Renal Function: A Prospective Cohort Study.
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Clinical Trials

Most Relevant Clinical Trials

  1. Pharmacokinetics in Subjects With Renal Impairment
  2. Fruquintinib Renal Impairment Study
  3. Surufatinib Renal Impairment Study
  4. Lorlatinib Renal Impairment Study
  5. Safinamide Renal Impairment Trial
Explore Clinical Trials Results
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