Correlation Engine 2.0
Clear Search sequence regions

  • antibiotics (2)
  • asian (1)
  • bacteria (3)
  • biofilms (7)
  • linezolid (1)
  • oxazolidinones (6)
  • Sizes of these terms reflect their relevance to your search.

    Biofilms are part of the natural lifecycle of bacteria and are known to cause chronic infections that are difficult to treat. Most antibiotics are developed and tested against bacteria in the planktonic state and are ineffective against bacterial biofilms. The oxazolidinones, including the last resort drug linezolid, are one of the main classes of synthetic antibiotics progressed to clinical use in the last 50 years. They have a unique mechanism of action and only develop low levels of resistance in the clinical setting. With the aim of providing insight into strategies to design more potent antibiotic compounds with activity against bacterial biofilms, we review the biofilm activity of clinically approved oxazolidinones and report on structural modifications to oxazolidinones and their delivery systems which lead to enhanced anti-biofilm activity. © 2022 The Authors. Chemistry - An Asian Journal published by Wiley-VCH GmbH.


    Audrey R N Ndukwe, Sandra Wiedbrauk, Nathan R B Boase, Kathryn E Fairfull-Smith. Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms. Chemistry, an Asian journal. 2022 Jun 01;17(11):e202200201

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35352479

    View Full Text