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Ge et al. (2022) describes an inhibitory, post-translational modification of PTEN at C211 by fumarate, which offers new insight into the integration of PI3K signaling and metabolism via a potential feedforward regulatory mechanism involving a PI3K-glucose-fumarate-PTEN axis. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Sally E Claridge, Benjamin D Hopkins. Circling back to PTEN: Fumarate inhibits canonical tumor suppressor. Molecular cell. 2022 Apr 07;82(7):1244-1245

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PMID: 35395197

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