Ge et al. (2022) describes an inhibitory, post-translational modification of PTEN at C211 by fumarate, which offers new insight into the integration of PI3K signaling and metabolism via a potential feedforward regulatory mechanism involving a PI3K-glucose-fumarate-PTEN axis. Copyright © 2022 Elsevier Inc. All rights reserved.
Sally E Claridge, Benjamin D Hopkins. Circling back to PTEN: Fumarate inhibits canonical tumor suppressor. Molecular cell. 2022 Apr 07;82(7):1244-1245
PMID: 35395197
View Full Text