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In this chapter, we will focus on HDLs' activity of inhibiting LDL oxidation and neutralizing some other oxidants. ApoA-I was known as the main antioxidant component in HDLs. The regulation of antioxidant capacity of HDL is mainly exhibited in regulation of apoA-I and alterations at the level of the HDL lipidome and the modifications of the proteome, especially MPO and PON1. HDL oxidation will influence the processes of inflammation and cholesterol transport, which are important processes in atherosclerosis, metabolic diseases, and many other diseases. In a word, HDL oxidation might be an effective antioxidant target in treatment of many diseases. © 2022. Springer Nature Singapore Pte Ltd.


Qi Zhang, Zongzhe Jiang, Yong Xu. HDL and Oxidation. Advances in experimental medicine and biology. 2022;1377:63-77

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PMID: 35575921

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