Enantioselective phosphonation of isoquinolines via chiral phosphoric acid-catalyzed dearomatization.

An efficient and enantioselective phosphonation protocol for construction of chiral α-aminophosphates and α-aminodiarylphosphine oxides has been developed based on chiral phosphoric acid-catalyzed dearomatization of isoquinolines. A series of chiral 1,2-dihydroisoquinolines with dimethoxy phosphoryl or diphenylphosphono substituents at the C1-position were constructed with good to excellent yields and enantioselectivities under mild reaction conditions.

Citation

Zhenhua Gao, Yongbiao Guo. Enantioselective phosphonation of isoquinolines via chiral phosphoric acid-catalyzed dearomatization. Chemical communications (Cambridge, England). 2022 Aug 18;58(67):9393-9396

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PMID: 35912502

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