Autoimmune Myelofibrosis in a 12-Year-old Male With Monosomy 7, Systemic Lupus Erythematous and Lupus Nephritis: A Case Report and Review of the Literature.

María G Español, Abdulla M Ehlayel, Minelys M Alicea Marrero, Renee V Gardner, María C Velez

Journal of pediatric hematology/oncology 2023 Jan 01

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Complete or partial loss of chromosome 7 is a common and well-known cytogenetic abnormality associated with preleukemic myelodysplasia and myeloid leukemia but not with autoimmune myelofibrosis. Detection of this molecular change represents poor prognosis. When malignant transformation occurs, the condition tends to be chemotherapy-resistant requiring haematopoietic stem cell transplantation (HSCT) to obtain a cure. Disappearance after immunosuppressive therapy has been documented in children with hematological disorders but not in association with cyclophosphamide and systemic lupus erythematous.We present the interesting case of a 12-year-old male with monosomy 7, systemic lupus erythematous, and lupus nephritis with the resolution of the monosomy 7 and autoimmune myelofibrosis after treatment with cyclophosphamide, along with a review of the literature. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Citation

María G Español, Abdulla M Ehlayel, Minelys M Alicea Marrero, Renee V Gardner, María C Velez. Autoimmune Myelofibrosis in a 12-Year-old Male With Monosomy 7, Systemic Lupus Erythematous and Lupus Nephritis: A Case Report and Review of the Literature. Journal of pediatric hematology/oncology. 2023 Jan 01;45(1):e1-e3