Rho family GTPase signaling through type II p21-activated kinases.

Ashwin K Chetty, Byung Hak Ha, Titus J Boggon

Cellular and molecular life sciences : CMLS 2022 Nov 19

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Signaling from the Rho family small GTPases controls a wide range of signaling outcomes. Key among the downstream effectors for many of the Rho GTPases are the p21-activated kinases, or PAK group. The PAK family comprises two types, the type I PAKs (PAK1, 2 and 3) and the type II PAKs (PAK4, 5 and 6), which have distinct structures and mechanisms of regulation. In this review, we discuss signal transduction from Rho GTPases with a focus on the type II PAKs. We discuss the role of PAKs in signal transduction pathways and selectivity of Rho GTPases for PAK family members. We consider the less well studied of the Rho GTPases and their PAK-related signaling. We then discuss the molecular basis for kinase domain recognition of substrates and for regulation of signaling. We conclude with a discussion of the role of PAKs in cross talk between Rho family small GTPases and the roles of PAKs in disease. © 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Citation

Ashwin K Chetty, Byung Hak Ha, Titus J Boggon. Rho family GTPase signaling through type II p21-activated kinases. Cellular and molecular life sciences : CMLS. 2022 Nov 19;79(12):598