The complement system testing in clinical laboratory.

Xuewei Ding, Ayub Qamar, Hui Liu

Clinica chimica acta; international journal of clinical chemistry 2023 Feb 15

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With the advancement in research in the field of the complement system, a more comprehensive understanding developed about the complement system's role in the life process of an organism. It is a system of innate immune surveillance. This system plays a pivotal role in host defense against pathogens, inflammation, B and T cell homeostasis. Complement system analysis has a significant advantage in the assessment of the immune system status, diagnosis and prognosis of diseases, and medication guidelines. Currently, complement system testing is neither yet widely used across all clinical laboratoriesnor are the testing protocols yet systematic. Based on the current research, it is suggested that the analysis of complement activator-activated complement activity and total complement activity would be comprehensively assessed to evaluate the complement system's immunological function, and combine of the detection of its components to establish a systematic protocol for the complement system testing in the clinical laboratory. This article reviews the complement system's physiological role, disease relevance and the current testing status in clinical laboratories. Further more, some suggestions have also been provided for the preparation of complement standards i.e., the standardized preparation process for complement standards seems to be a feasible option given the easy inactivation of complement. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Xuewei Ding, Ayub Qamar, Hui Liu. The complement system testing in clinical laboratory. Clinica chimica acta; international journal of clinical chemistry. 2023 Feb 15;541:117238