Clinical factors associated with skin neoplasms in individuals with Lynch syndrome in a longitudinal observational cohort.

Little is known about patient-specific risk factors for skin neoplasia in individuals with Lynch syndrome (LS). Identify clinical factors associated with development of skin neoplasms in LS. Clinical data were systematically collected on a cohort of LS carriers (confirmed pathogenic germline variants in MLH1, MSH2, MSH6, PMS2, or EPCAM) age ≥18 undergoing clinical genetics care at Dana-Farber Cancer Institute from January 2000 to March 2020. Multivariable logistic regression was performed to evaluate clinical factors associated with skin neoplasia. Of 607 LS carriers, 9.2% had LS-associated skin neoplasia and 15.0% had non-LS-associated skin neoplasia; 58.2% (353/607) had documentation of prior dermatologic evaluation; 29.7% (38/128) with skin neoplasms lacked a history of visceral LS-associated malignancy. LS-associated skin neoplasms were significantly associated with male sex, age, race, MLH1 pathogenic germline variants, MSH2/EPCAM pathogenic germline variants, and personal history of non-LS skin neoplasms. Non-LS-associated skin neoplasms was significantly associated with age, number of first- and second-degree relatives with non-LS-associated skin neoplasms, and personal history of LS-associated skin neoplasms. Single-institution observational study; demographic homogeneity. Skin neoplasms are common in individuals with LS. We identified clinical factors associated with LS- and non-LS-associated skin neoplasms. Regular dermatologic surveillance should be considered for all LS carriers. Copyright © 2023 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Citation

Connie S Zhong, Miki Horiguchi, Hajime Uno, Chinedu Ukaegbu, Anu Chittenden, Nicole R LeBoeuf, Sapna Syngal, Vinod E Nambudiri, Matthew B Yurgelun. Clinical factors associated with skin neoplasms in individuals with Lynch syndrome in a longitudinal observational cohort. Journal of the American Academy of Dermatology. 2023 Jun;88(6):1282-1290

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PMID: 36773823

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