A Case of Long-Term Survival with Tumor Resection and DOX plus DTIC Therapy for Desmoid Tumor after FAP Surgery].

Gan to kagaku ryoho. Cancer & chemotherapy 2023 Mar

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The patient is a 22-year-old, female. She had a family history of familial adenomatous polyposis(FAP)and a prophylactic total colorectal resection was performed for FAP at age of 18. She presented with fever and abdominal distention and palpated a mass with tenderness in the right lower abdomen. Contrast-enhanced CT scan of the abdomen showed a heterogeneous contrast effect around the tumor margins. With the diagnosis of intra-abdominal desmoid tumor, a partial duodenal resection, small bowel mass resection, and right fallopian tube resection were performed along with the tumor, and an artificial anus was created with the jejunum. Contrast-enhanced CT scan of the abdomen 16 months after resection of desmoid tumor showed a 6.5 cm long desmoid tumor recurrence in the mesentery. She received 5 courses of doxorubicin (DOX)plus dacarbazine(DTIC)therapy followed by continued NSAIDs. Seven years after the operation, she has been able to maintain the shrinkage of the recurrent tumor and is still on medication. Long-term surveillance is necessary because of the possibility of the appearance of other associated lesions in the future.

Citation

Takashi Takeda, Katsuki Danno, Shiki Fujino, Itsuko Nakamichi, Naoya Takada, Shuhei Murao, Kei Yamamoto, Masaya Higashiguchi, Kozo Noguchi, Yasuhiro Toyoda, Shigeru Nakane, Hitoshi Yamamoto, Takafumi Hirao, Yoshio Oka. A Case of Long-Term Survival with Tumor Resection and DOX plus DTIC Therapy for Desmoid Tumor after FAP Surgery]. Gan to kagaku ryoho. Cancer & chemotherapy. 2023 Mar;50(3):401-403