INTRAVITREAL METHOTREXATE IN VEMURAFENIB-INDUCED UVEITIS.

Vemurafenib, a BRAF inhibitor, has revolutionized the prognosis of late-stage melanoma patients, rising at the same time concerns about its potential adverse effects. Here is a case of vemurafenib-induced uveitis, peculiar in both its presentation and management. Case report, diagnostic, and therapeutic challenge. Uveitis is a known side effect of vemurafenib. It is generally bilateral, moderate, manageable with topical steroids, and does not require cancer therapy cessation. We present a patient who suffered from a unilateral, severe uveitis after vemurafenib treatment that fully recovered thanks to intravitreal methotrexate injections because conventional corticosteroid therapy was contraindicated. Uveitis can be a serious ocular adverse effect of vemurafenib, whereas its risk factors and mechanisms remain unknown. As BRAF inhibitors are now used on a regular basis, it is important for clinicians to be aware of this potentially sight-threatening side effect. Intravitreal methotrexate injections may be considered as an effective treatment choice in severe targeted agents-induced uveitis.

Citation

Artémise Dugauquier, Ahmad Hussein Awada, Elie Motulsky, Nacima Kisma. INTRAVITREAL METHOTREXATE IN VEMURAFENIB-INDUCED UVEITIS. Retinal cases & brief reports. 2024 Jul 01;18(4):455-458

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PMID: 36977328

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