Pan Luo, Yanfei Gong, Jie Weng, Fang Wen, Jin Luo, Chun Hu, Jun Xiao, Jinyong Shu
Cellular signalling 2023 AugTriple-negative breast cancer (TNBC) is recognized for its poor prognosis and limited options for treatment. Circular RNA KIF4A (circKIF4A) was documented to be abnormally overexpressed in TNBC and was correlated with a poor survival rate. The objective of this study is to further examine the functional role of circKIF4A and its underlying mechanism. CircKIF4A was significantly upregulated in TNBC and the knockdown of circKIF4A suppressed TNBC cell proliferation, migration, and invasion. CircKIF4A was directly bound to EIF4A3, which interacted with SDC1. Knockdown of circKIF4A reduced interaction between EIF4A3 and SDC1 as well as SDC1 mRNA stability. SDC1 activated the c-src/FAK signaling pathways and finally promoted TNBC progression. circKIF4A induced TNBC progress in the in vivo mouse model via SDC1. CircKIF4A interacts with EIF4A3 to stabilize SDC1 mRNA, which activates the c-src/FAK signaling pathways and promotes TNBC progression. This may provide a potential therapy for TNBC treatment. Copyright © 2023. Published by Elsevier Inc.
Pan Luo, Yanfei Gong, Jie Weng, Fang Wen, Jin Luo, Chun Hu, Jun Xiao, Jinyong Shu. CircKIF4A combines EIF4A3 to stabilize SDC1 expression to activate c-src/FAK and promotes TNBC progression. Cellular signalling. 2023 Aug;108:110690
PMID: 37121557
View Full Text