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The reduced tumor suppression activity of hypomorphic variants of the TP53 gene was used by Indeglia and colleagues to corroborate PADI4 as a p53 target. The study makes a noteworthy advancement in comprehending the downstream implications of TP53-PDI4, including potential predictions of survival and the efficacy of immunotherapy. See related article by Indeglia et al., p. 1696 (4). ©2023 American Association for Cancer Research.


Bibek Bhatta, Tomer Cooks. Identifying p53 Target Genes Using Hypomorphic Variants. Cancer discovery. 2023 Jul 07;13(7):1518-1520

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PMID: 37416992

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