An Enigmatic Case of Skeletal Fluorosis: Inhalant-Induced Toxicity.

Kara M DeMarco, Joshua W Major, Colin R Young, Arash Hassantoufighi

Clinical nuclear medicine 2023 Oct 01

filter terms:

Skeletal fluorosis is more common in the developing world, but is occasionally seen in the United States. We present radiographic, scintigraphic, CT, and clinical images of a 26-year-old woman with rapidly progressive, debilitating, polyostotic periostitis, and diffuse osteosclerosis typical of skeletal fluorosis. Laboratory analyses supported this diagnosis. The source of excess fluoride intake was elusive until a concurrent mental health workup revealed the patient's proclivity for inhaling air-duster cans containing difluoroethane. Difluoroethane inhalant abuse is an increasingly reported cause of skeletal fluorosis that astute clinicians should recognize. Discontinuation and sobriety from this toxic agent are essential for recovery. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Kara M DeMarco, Joshua W Major, Colin R Young, Arash Hassantoufighi. An Enigmatic Case of Skeletal Fluorosis: Inhalant-Induced Toxicity. Clinical nuclear medicine. 2023 Oct 01;48(10):e487-e488