Presenilins and mitochondria-an intriguing link: mini-review.

This review uncovers the intricate relationship between presenilins, calcium, and mitochondria in the context of Alzheimer's disease (AD), with a particular focus on the involvement of presenilin mutations in mitochondrial dysfunction. So far, it is unclear whether the impairment of mitochondrial function arises primarily from damage inflicted by β-amyloid upon mitochondria or from the disruption of calcium homeostasis due to presenilins dysfunctions. The roles of presenilins in mitophagy, autophagy, mitochondrial dynamics, and many other functions, non-γ-secretase related, also require close attention in future research. Resolution of contradictions in understanding of presenilins cellular functions are needed for new effective therapeutic strategies for AD. Copyright © 2023 Makarov, Kushnireva, Papa and Korkotian.

Citation

Mark Makarov, Liliia Kushnireva, Michele Papa, Eduard Korkotian. Presenilins and mitochondria-an intriguing link: mini-review. Frontiers in neuroscience. 2023;17:1249815

PMID: 37575294

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