Starvation induces hepatopancreas atrophy in Chinese mitten crab (Eriocheir sinensis) by inhibiting angiogenesis.

Hongli Liu, Yang Feng, Ma Yang, Ya Huang, Minghao Li, Yi Geng, Ping Ouyang, Defang Chen, Shiyong Yang, Lizi Yin, Liangyu Li, Xiaoli Huang

BMC genomics 2023 Oct 12

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The hepatopancreas of crustaceans serves as a significant organ for both the synthesis and secretion of digestive enzymes, as well as energy storage. In the event of food shortage, the hepatopancreas can provide energy for survival. To investigate the potential regulatory mechanisms of the hepatopancreas in response to starvation in Eriocheir Sinensis, transcriptome analysis, histological study and qRT-PCR were performed. The results showed that starvation caused a decrease in the hepatopancreas index of E. sinensis, which had certain effects on the tissue structure, metabolism and angiogenesis in the hepatopancreas. In addition, WGCNA and linear regression analysis showed that the genes significantly related to the hepatopancreas index were mainly enriched in the angiogenesis pathway, in which AKT signaling played an important role. Starvation may inhibit AKT signaling pathway by reducing the expression of TGFBI, HSP27, HHEX, and EsPVF1, thereby hindering angiogenesis, promoting apoptosis, and leading to hepatopancreas atrophy. These results indicate that AKT plays an important role in the angiogenesis pathway and apoptosis of the starvation induced hepatopancreas index reduction, which is beneficial to further understand the effect of starvation stress on hepatopancreas of Chinese mitten crab. © 2023. BioMed Central Ltd., part of Springer Nature.

Citation

Hongli Liu, Yang Feng, Ma Yang, Ya Huang, Minghao Li, Yi Geng, Ping Ouyang, Defang Chen, Shiyong Yang, Lizi Yin, Liangyu Li, Xiaoli Huang. Starvation induces hepatopancreas atrophy in Chinese mitten crab (Eriocheir sinensis) by inhibiting angiogenesis. BMC genomics. 2023 Oct 12;24(1):612