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TREX-2-ORC Complex of D. melanogaster Participates in Nuclear Export of Histone mRNA.

M M Kurshakova, Y A Yakusheva, S G Georgieva

Doklady. Biochemistry and biophysics 2024 Feb


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  • cell nucleus (2)
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  • drosophila (1)
  • nuclear export (2)
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  • protein complex (1)
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    The TREX-2-ORC protein complex of D. melanogaster is necessary for the export of the bulk of synthesized poly(A)-containing mRNA molecules from the nucleus to the cytoplasm through the nuclear pores. However, the role of this complex in the export of other types of RNA remains unknown. We have shown that TREX-2-ORC participates in the nuclear export of histone mRNAs: it associates with histone mRNPs, binds to histone H3 mRNA at the 3'-terminal part of the coding region, and participates in the export of histone mRNAs from the nucleus to the cytoplasm. © 2024. The Author(s).

    Citation

    M M Kurshakova, Y A Yakusheva, S G Georgieva. TREX-2-ORC Complex of D. melanogaster Participates in Nuclear Export of Histone mRNA. Doklady. Biochemistry and biophysics. 2024 Feb;514(1):11-15

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    PMID: 38189888

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