Novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and aggressive presentation.

Childhood melanoma is a rare and biologically heterogeneous pediatric malignancy. The differential diagnosis of pediatric melanoma is usually broad, including a wide variety of spindle cell or epithelioid neoplasms. Different molecular alterations affecting the MAPK and PI3K/AKT/mTOR pathways, tumor suppressor genes, and telomerase reactivation have been implicated in melanoma tumorigenesis and progression. Here, we report a novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and an aggressive clinical course. © 2024 Wiley Periodicals LLC.

Citation

Larissa V Furtado, Maria Cardenas, Teresa Santiago, Robert E Ruiz, Zonggao Shi, Alberto Pappo, Marija Kacar. Novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and aggressive presentation. Genes, chromosomes & cancer. 2024 Mar;63(3):e23230

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PMID: 38459940

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