WW domains: A globular NLS recognized by importin-α.

Natalia Elisa Bernardes, Yuh Min Chook

The Journal of cell biology 2024 Jun 03

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In this issue, the discovery by Yang et al. (https://doi.org/10.1083/jcb.202308013) that folded WW domains of YAP1 and other proteins bind to Impα introduces a new class of globular NLS, contrasting with the extensively studied linear NLS motifs. This finding underscores the versatility of importins in recognizing their cargo proteins. © 2024 Bernardes and Chook.