Clinical Characteristics and Outcomes of CML in Adolescents and Young Adults.

Clinical lymphoma, myeloma & leukemia 2024 Oct

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While Chronic Myeloid Leukemia (CML) is a disease of older adults, there is a growing population of adolescent and young adults (AYAs) with CML. This study evaluated the clinical characteristics and outcomes of CML in AYAs. Data from medical records of adults with chronic phase CML diagnosed and treated at our center from 2011until 2021were retrospectively analyzed. Age between 18 and 29 years was used to define AYAs. Response to tyrosine kinase inhibitors (TKIs), progression to accelerated phase (AP) or blast crisis (BC), event-free survival (EFS) and overall survival (OS) were compared between AYAs and older adults. Among 163 patients included, 41 (25.1%) were AYAs. AYAs were more likely to be males (P = .02), to present with symptoms (P = .004), had a higher median white blood cell count (P = .007), neutrophil count (P = .029), eosinophil count (P = 0.01), low-risk Sokal (P = .033) and Hasford (P = .005) groups. TKI-sensitivity as well as median times for achievement of complete cytogenetic and major molecular response were comparable between both groups. After a median follow-up of 76 (range: 11-235) months, there was no difference in OS (P = .528), or cumulative incidence of transformation to accelerated phase or blast crisis (P = .11). On the other hand, AYA had an inferior EFS (P = .034). A quarter of the patients diagnosed with CML in our population were AYAs. Despite being characterized as "lower-risk," they presented with a greater disease burden, had a shorter EFS but comparable OS. Further studies are needed to better understand the disease biology of this group. Copyright © 2024 Elsevier Inc. All rights reserved.

Citation

Kamal Al-Rabi, Mohammad Ma'koseh, Fadwa Al-Qadi, Ali A Hanoon, Waleed Da'na, Abdallah J Asha, Zaid Abdel Rahman, Lina Marie, Omar Shahin, Roa'a Ma'koseh, Akram Al-Ibraheem, Anas Zayed, Abeer Yaseen, Saleh Al-Rabee, Heba Farfoura, Hikmat Abdel-Razeq. Clinical Characteristics and Outcomes of CML in Adolescents and Young Adults. Clinical lymphoma, myeloma & leukemia. 2024 Oct;24(10):715-723