Inositol lipid-mediated intranuclear signalling: a comparative analysis of in vivo labelling in interferon alpha-sensitive and -resistant Daudi lymphoma cells.

A Cataldi, R Di Primio, R Lisio, R A Rana, I Robuffo, D Bosco, S Miscia

Istituto di Morfologia Umana Normale, Università G. D'Annunzio, Chieti, Italy.

Cellular signalling 1993 May

filter terms:

Changes in inositol lipid and diacylglycerol metabolism have been analysed in Daudi lymphoma cells treated up to 24 h with human DNA recombinant interferon alpha. Results showing a different response of nuclear phosphoinositides and diacylglycerol, compared to whole cells, suggest that the intranuclear signalling system activated by interferon in Daudi cells involves nuclear inositol lipid metabolism. A well-characterized clone of Daudi cells selected for resistance to the antiproliferative action of interferon provided controls for the specificity of results.

Citation

A Cataldi, R Di Primio, R Lisio, R A Rana, I Robuffo, D Bosco, S Miscia. Inositol lipid-mediated intranuclear signalling: a comparative analysis of in vivo labelling in interferon alpha-sensitive and -resistant Daudi lymphoma cells. Cellular signalling. 1993 May;5(3):331-6