Homobotcinolide: a biologically active natural homolog of botcinolide from Botrytis cinerea.

H G Cutler, S R Parker, S A Ross, F G Crumley, P R Schreiner

USDA, ARS, Richard B. Russell Research Center, Athens, Georgia 30613, USA.

Bioscience, biotechnology, and biochemistry 1996 Apr

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A novel natural product exhibiting biological activity was isolated from a strain of Botrytis cinerea that had infected raspberry fruit (Rubus ideaus). Liquid fermentation and bioassay-directed fractionation of the organism yielded a compound with molecular formula C22H38O8 that is trivially named homobotcinolide. It significantly inhibited etiolated wheat coleoptile growth. Greenhouse-grown bean, corn, and tobacco plants were also affected by exogenous application of homobotcinolide, severe chlorosis and necrosis being exhibited in corn. The compound is a polyhydroxylated nonalactone esterified with 4-hydroxy-2-decenoic acid.

Citation

H G Cutler, S R Parker, S A Ross, F G Crumley, P R Schreiner. Homobotcinolide: a biologically active natural homolog of botcinolide from Botrytis cinerea. Bioscience, biotechnology, and biochemistry. 1996 Apr;60(4):656-8