QuickView for ADGRB1;jsessionid=9CAD6E748DF0CE512A18DECAAE86D165 (gene)

Gene Symbol:

ADGRB1 Homo sapiens

Full name:

adhesion G protein-coupled receptor B1

Synonyms:

BAI1, GDAIF, adhesion G protein-coupled receptor B1, brain-specific angiogenesis inhibitor 1

Genomic Location:

Chr 8: 143542379-143623370

Description:

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vess...

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Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGATGC_MIR3245P ,  GGGACCA_MIR133A_MIR133B ,  VDR_Q6 ,  E2F_Q6_01 ,  P53_02 ,  CTCAGGG_MIR125B_MIR125A ,  ATGCTGC_MIR103_MIR107 ,  E2F_Q4_01 ,  TCTCTCC_MIR185 ,  GAGCCAG_MIR149 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-149

Cytogenetic Map:

8q24.3

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