QuickView for ASB2;jsessionid=FFD94239546FFF70E6460E29F0DE025A (gene)

Gene Symbol:

ASB2 Homo sapiens

Full name:

ankyrin repeat and SOCS box containing 2

Synonyms:

ASB-2, ankyrin repeat and SOCS box protein 2, ankyrin repeat and SOCS box-containing protein 2a

Genomic Location:

Chr 14: 93470266-93493520

Description:

This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of acti...

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This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_Q6_01 ,  NFMUE1_Q6 ,  SRF_01 ,  HEN1_01 ,  YTATTTTNR_MEF2_02 ,  SMAD3_Q6 ,  TTF1_Q6 ,  GGGAGGRR_MAZ_Q6 ,  GGATTA_PITX2_Q2 ,  RREB1_01 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  GR_Q6 ,  EVI1_02 ,  HNF4_Q6 ,  E47_01 ,  YY1_02 ,  HEN1_02 ,  RGAGGAARY_PU1_Q6 ,  TAL1BETAITF2_01 ,  SRF_Q5_01 ,  CAGCTG_AP4_Q5 ,  EVI1_01 ,  SRF_C ,  CP2_01 ,  TCF11MAFG_01

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Cytogenetic Map:

14q32.12

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