Name: | 1-hydroxycholecalciferol |
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PubChem Compound ID: | 10501623 |
Molecular formula: | C27H44O2 |
Molecular weight: | 408.669 g/mol |
Name: | 1-hydroxycholecalciferol |
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Name (isomeric): | DB01436 |
Drug Type: | small molecule |
Synonyms: |
1alpha-hydroxyvitamin D3; 1alpha-hydroxycholecalciferol; 1-hydroxycholecalciferol
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Brand: | Alsiodol, One Alpha |
Category: | Bone Density Conservation Agents |
CAS number: | 41294-56-8 |
Indication: | Alfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. |
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Pharmacology: | Alfacalcidol is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. |
Mechanism of Action: |
The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed by the 25-hydroxylase in the liver and then by other enzymes. The mitochondrial sterol 27-hydroxylase catalyses the first reaction in the oxidation of the side chain of sterol intermediates. The active form of vitamin D3 (calcitriol) binds to intracellu...
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Toxicity: | Hypercalcemia - Early symptoms of hypercalcemia, include nausea and vomiting, weakness, headache, somnolence, dry mouth, constipation, metallic taste, muscle pain and bone pain. Late symptoms and signs of hypercalcemia, include polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritis, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated ALT (SGPT) and AST (SGOT), ectopic calcification, nephrocalcinosis, hypertension and cardiac arrhythmias. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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