QuickView for BB2 (gene)

Gene Symbol:

GRPR Homo sapiens

Full name:

gastrin releasing peptide receptor

Synonyms:

BB2, BB2R, gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, bombesin receptor 2

Genomic Location:

Chr X: 16051345-16081562

Description:

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide rece...

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Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

POU6F1_01 ,  TTANTCA_UNKNOWN ,  WGTTNNNNNAAA_UNKNOWN ,  DBP_Q6 ,  GTGACGY_E4F1_Q6 ,  LHX3_01 ,  S8_01 ,  CTTTAAR_UNKNOWN ,  GFI1_01 ,  AFP1_Q6 ,  CTGCAGY_UNKNOWN ,  CCANNAGRKGGC_UNKNOWN ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN

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Cytogenetic Map:

Xp22.2

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