QuickView for BPNT1;jsessionid=F31F9D11D3A8B30167A32FF0A9FF3749 (gene)

Gene Symbol:

BPNT1 Homo sapiens

Full name:

3'(2'), 5'-bisphosphate nucleotidase 1

Synonyms:

HEL20, PIP, 3'(2'),5'-bisphosphate nucleotidase 1, BPntase, PAP-inositol-1,4-phosphatase, bisphosphate 3'-nucleotidase 1, epididymis luminal protein 20, testicular tissue protein Li 29

Genomic Location:

Chr 1: 218297447-218329814

Description:

BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may...

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BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTATGCA_MIR153 ,  ACATTCC_MIR1_MIR206 ,  AACATTC_MIR4093P

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-409-3p

Cytogenetic Map:

1q41

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