QuickView for BRMS1;jsessionid=14FDF67AE0116F621C115725267045F4 (gene)

Gene Symbol:

BRMS1 Homo sapiens

Full name:

breast cancer metastasis suppressor 1

Synonyms:

breast cancer metastasis-suppressor 1

Genomic Location:

Chr 11: 65861380-65869158

Description:

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper ...

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This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CREB_Q3 ,  TCCCRNNRTGC_UNKNOWN ,  TITF1_Q3 ,  YYCATTCAWW_UNKNOWN ,  TEF1_Q6 ,  FREAC3_01 ,  CREB_02 ,  GKCGCNNNNNNNTGAYG_UNKNOWN ,  ER_Q6_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145

Cytogenetic Map:

11q13.2

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