QuickView for Bmp6 (gene)

Gene Symbol:

BMP6 Homo sapiens

Full name:

bone morphogenetic protein 6

Synonyms:

VGR, VGR1, bone morphogenetic protein 6, VG-1-R, VG-1-related protein, vegetal related growth factor (TGFB-related)

Genomic Location:

Chr 6: 7672010-7826960

Description:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subuni...

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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  E12_Q6 ,  USF_Q6 ,  EFC_Q6 ,  MIF1_01 ,  GATA3_01 ,  GATA_Q6 ,  GATA_C ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  GCANCTGNY_MYOD_Q6 ,  MAX_01 ,  RNCTGNYNRNCTGNY_UNKNOWN ,  GATAAGR_GATA_C ,  RFX1_01 ,  GATA1_04 ,  GGGYGTGNY_UNKNOWN ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  TGCCTTA_MIR124A ,  NF1_Q6 ,  LMO2COM_02 ,  GATA6_01 ,  HIF1_Q5 ,  NF1_Q6_01 ,  GATA1_02 ,  RNGTGGGC_UNKNOWN ,  RYTGCNNRGNAAC_MIF1_01 ,  WTTGKCTG_UNKNOWN ,  CAGCTG_AP4_Q5 ,  USF_02 ,  HIF1_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

Cytogenetic Map:

6p24.3

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