QuickView for CBFA2 (gene)

Gene Symbol:

RUNX1 Homo sapiens

Full name:

runt related transcription factor 1

Synonyms:

AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, runt-related transcription factor 1, AML1-EVI-1 fusion protein, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, acute myeloid leukemia 1 protein, core-binding factor, runt domain, alpha subunit 2, oncogene AML-1, polyomavirus enhancer-binding protein 2 alpha B subunit

Genomic Location:

Chr 21: 35081968-35343465

Description:

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have b...

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Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  E12_Q6 ,  GATTGGY_NFY_Q6_01 ,  MYOD_Q6_01 ,  OCT1_07 ,  RTAAACA_FREAC2_01 ,  GTGTTGA_MIR505 ,  TGANTCA_AP1_C ,  AAGCCAT_MIR135A_MIR135B ,  TTANTCA_UNKNOWN ,  OCT1_04 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  AML_Q6 ,  FOXO4_01 ,  CTACTGT_MIR199A ,  GCANCTGNY_MYOD_Q6 ,  FOXD3_01 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  GGAMTNNNNNTCCY_UNKNOWN ,  CAGTGTT_MIR141_MIR200A ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  FAC1_01 ,  CTTTGA_LEF1_Q2 ,  E2A_Q2 ,  GTGCAAA_MIR507 ,  EGR2_01 ,  ACTGTGA_MIR27A_MIR27B ,  CTTTGTA_MIR524 ,  OSF2_Q6 ,  TGAYRTCA_ATF3_Q6 ,  GCACCTT_MIR18A_MIR18B ,  YYCATTCAWW_UNKNOWN ,  RP58_01 ,  RREB1_01 ,  CAGGTG_E12_Q6 ,  AP4_Q6 ,  CAGCTTT_MIR320 ,  SP3_Q3 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  NF1_Q6 ,  GCAAAAA_MIR129 ,  CATRRAGC_UNKNOWN ,  TGCTGAY_UNKNOWN ,  PITX2_Q2 ,  LMO2COM_02 ,  AHR_Q5 ,  FOXO1_01 ,  E47_01 ,  HFH4_01 ,  POU1F1_Q6 ,  NF1_Q6_01 ,  HFH8_01 ,  RACCACAR_AML_Q6 ,  AHRARNT_01 ,  YCATTAA_UNKNOWN ,  NCX_01 ,  OCT1_02 ,  TTGTTT_FOXO4_01 ,  PAX_Q6 ,  AGGGCAG_MIR18A ,  TGACAGNY_MEIS1_01 ,  EGR1_01 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  YNGTTNNNATT_UNKNOWN ,  TGACATY_UNKNOWN ,  USF_02 ,  HNF1_Q6 ,  COREBINDINGFACTOR_Q6 ,  NFKB_Q6 ,  FOXO4_02 ,  HNF6_Q6 ,  CACTTTG_MIR520G_MIR520H ,  LMO2COM_01 ,  STAT5A_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-192 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-504 ,  Predicted Gene Targets for miR-505

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miRNA binding sites
(Source: miRecords):

hsa-miR-106a Targeted Genes ,  hsa-miR-17 Targeted Genes ,  hsa-miR-20a Targeted Genes

Cytogenetic Map:

21q22.12

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