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QuickView for CHRONOPHIN (gene)


Gene Symbol:
PDXP Homo sapiens Homo sapiens
Full name:
pyridoxal phosphatase
Synonyms:
CIN, PLP, dJ37E16.5, pyridoxal phosphate phosphatase, PLP phosphatase, chronophin, pyridoxal (pyridoxine, vitamin B6) phosphatase, testicular secretory protein Li 36
Genomic Location:
Chr 22: 36384683-36392885
Description:
Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).
Orthologs:
Mus musculus Rattus norvegicus Bos taurus Danio rerio Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 22
22q13.1


Transcripts Names
NM_020315
Protein Names
Q96GD0
Q9UGY2
A0A024R1I3



GO Molecular Function

cation binding | magnesium ion binding | phosphatase activity | hydrolase activity | catalytic activity | phosphoprotein phosphatase activity | hydrolase activity, acting on ester bonds | identical protein binding | ion binding | protein binding | protein homodimerization activity | protein dimerization activity | phosphoric ester hydrolase activity | phosphoserine phosphatase activity | pyridoxal phosphatase activity | heat shock protein binding | metal ion binding

GO Biological Process

response to extracellular stimulus | regulation of supramolecular fiber organization | regulation of cell cycle process | response to nutrient levels | actin filament-based process | response to ATP | protein dephosphorylation | positive regulation of cellular component organization | actin filament bundle organization | actin rod assembly | actin cytoskeleton organization | vitamin B6 catabolic process | cellular response to extracellular stimulus | response to drug | organophosphate catabolic process | regulation of organelle organization | regulation of actin polymerization or depolymerization | response to organophosphorus | cellular process | organic substance catabolic process | regulation of mitotic nuclear division | positive regulation of actin filament depolymerization | regulation of cell cycle | regulation of cellular process | catabolic process | positive regulation of protein complex disassembly | organic cyclic compound metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | regulation of cell division | regulation of actin filament length | phosphatase activity | response to stimulus | supramolecular fiber organization | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | regulation of cellular component size | cofactor metabolic process | cellular component assembly | protein modification process | macromolecule modification | drug catabolic process | organic hydroxy compound metabolic process | response to nitrogen compound | cellular response to nutrient levels | nitrogen compound metabolic process | positive regulation of organelle organization | regulation of actin cytoskeleton organization | phosphorus metabolic process | response to purine-containing compound | regulation of actin filament organization | actin filament organization | regulation of protein complex disassembly | cellular response to ATP | organophosphate metabolic process | phosphoprotein phosphatase activity | small molecule metabolic process | response to nutrient | positive regulation of protein depolymerization | actin filament bundle assembly | phosphate-containing compound metabolic process | cellular response to drug | cell communication | regulation of cytokinesis | regulation of actin filament depolymerization | positive regulation of cytoskeleton organization | aromatic compound catabolic process | regulation of protein depolymerization | regulation of mitotic cell cycle | drug metabolic process | cellular aldehyde metabolic process | protein metabolic process | cellular response to nutrient | response to organic substance | vitamin metabolic process | metabolic process | positive regulation of supramolecular fiber organization | organic substance metabolic process | cytoskeleton organization | phosphoserine phosphatase activity | organonitrogen compound catabolic process | dephosphorylation | response to organic cyclic compound | cellular protein metabolic process | aldehyde catabolic process | pyridoxal phosphatase activity | organelle organization | pyridoxal phosphate catabolic process | cellular protein modification process | response to organonitrogen compound | heterocycle metabolic process | regulation of actin filament-based process | cellular metabolic process | cellular response to organic substance | regulation of cellular component organization | vitamin B6 metabolic process | regulation of cytoskeleton organization | macromolecule metabolic process

GO Cellular Component

cleavage furrow | ruffle | cell projection membrane | cell | ruffle membrane | lamellipodium | cytoplasm | intracellular organelle | actin cytoskeleton | leading edge membrane | cell-cell junction | cell projection | contractile ring | plasma membrane | midbody | cell leading edge | organelle | cell division site | cell periphery | cytosol | cytoskeleton | intracellular | cell junction | membrane | lamellipodium membrane