QuickView for CLEC4H1 (gene)

Gene Symbol:

ASGR1 Homo sapiens

Full name:

asialoglycoprotein receptor 1

Synonyms:

ASGPR, ASGPR1, CLEC4H1, HL-1, asialoglycoprotein receptor 1, C-type lectin domain family 4 member H1, hepatic lectin H1

Genomic Location:

Chr 17: 7017474-7023386

Description:

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitat...

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This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CEBP_Q2_01 ,  GGGAGGRR_MAZ_Q6 ,  CEBPB_01 ,  CEBPB_02 ,  GCCNNNWTAAR_UNKNOWN ,  TGACATY_UNKNOWN

Cytogenetic Map:

17p13.1

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